Mesenchymal stem cell (MSCs) therapy has been considered a promising approach for treatment like Parkinson’s disease (PD). Parkinson’s diseases (PD) are the fastest growing among all neurological diseases which leading cause of disability worldwide

Parkinson’s disease (PD) is a complex age-related disorder that mainly affects individuals who age over 65, and it’s characterized by the degeneration of dopaminergic neurons in the substantia nigra, leading to both motor and non-motor deficits due to decreased dopamine (DA) levels in the striatum.

Common symptoms of Parkinson’s Disease

• Tremor – This is the most common and prominent symptom. It typically begins in one hand and usually affects only one side of the body at first. The tremor occurs while at rest and tends to lessen when the hand is in use
• Rigidity – This often occurs in the same arm or leg as the tremor and causes significant discomfort for the patient. It leads to slower movements. Additionally, patients may notice changes in their handwriting (small, cramped handwriting)
• Bradykinesia (slowness of movement) and Hypokinesia (reduced movement) – These symptoms cause a delay in initiating body movements and a general reduction in movement
• Postural instability – Patients may show signs of imbalance. Their gait is typically characterized by short, rapid steps, a stooped posture, and a lack of arm swing while walking

Currently, there is no cure for Parkinson’s disease (PD) and most treatments mainly focus on managing symptoms. Withmedicine treatments like levodopa can cause unwanted side effects like dyskinesia and they do not slow disease progression.

Unlike cell therapies that aim to provide patients with long-term symptom relief and replace degeneration neurons.

MSCs (Mesenchymal Stem Cell) offer distinct advantages due to their multipotency, immunomodulatory effect, self-renewal ability, migratory capacity, long-term survival and low ethical concerns specially when derived from sources like umbilical cord tissue. Specially, MSCs secrete a range of neurotrophic factors

• Including glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), fibroblast growth factors (FGF2 and FGF8), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), ciliary neurotrophic factor (CNTF), and stromal cell-derived factor-1 (SDF-1)

These factors may support dopaminergic neuron survival, inhibit apoptosis, and promote neurogenesis

• Suppressing overactive microglia (brain immune cells)
• Reducing pro-inflammatory cytokines (such as TNF-Œ±, IL-1Œ≤)
• Creating a neuroprotective environment that slows down disease progression

courtesy of Dr Prem Pillay

MSCs have been investigated for use in many different kind of diseases such as neurodegenerative, autoimmune, inflammatory, skin, respiratory, neuromuscular and hematological diseases

MSCs hold significant promises as a form of regenerative medicine with their unique properties like the secretion of trophic factors, modulation of immune system, enhancement of damage tissues and minimal ethical concerns.

Many clinic trials have reported motor function improvements in patients with Parkinson’s disease (improve motor control, reduce bradykinesia and tremor, lower UPDRS motors scores in some patients) after receiving MSC therapy with no side effects were observe

About EDNA Wellness

Located in Bangkok, EDNA Wellness is a private clinic specializing in Stem Cell Therapy for Neurology & Stroke as well as Bones & Joints. Beyond rehabilitation, we also provide aesthetic and wellness treatments to support your full-body vitality. All delivered with expert care and compassion

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Reference:

frontiers: Mesenchymal stem cell therapy for neurological disorders

frontiers: Long-term, repeated doses of intravenous autologous mesenchymal stem cells for a patient with Parkinson’s disease

Stem Cell Research & Therapy: Manipulated mesenchymal stem cell therapy in the treatment of Parkinson’s disease Neuroscience Applied: Research progress of cell treatment strategy in Parkinson’s disease